Destinee W's Answer

QOTD: “Alien vs Predator? Homer Simpson on Family Guy? What's the best crossover or cameo ever?”

New York, NY

James Franco appeared in General Hospital - very, very surprised!

“My favorite TV cameo is when James Franco appeared in General Hospital, just because it's like how random it was for me, I've only seen him in movies and this for me - to actually see him in General Hospital - I was very, very surprised.”
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Supernatural and Scooby Doo
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Grey's Anatomy and Station 19 crossovers
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Marie E's answer
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Claudia Schiffer in the movie "Love, Actually."
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